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Som beskrevet ovenfor kan man opleve medicinoverforbrugshovedpine ved anvendelse af paracetamol i længere perioder advertisement gangen.I slutningen af 1800-tallet fandt en tysk kemiker ud af, at virkningen skyldes stoffet acetylsalicylsyre. Det fik lægemiddelfirmaet Bayer til at udvikle Aspirin og senere Kodimagnyl, der hurtigt blev en stor succ

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